Related Experiment Video

Updated: Aug 7, 2026

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
05:04

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Published on: November 19, 2020

4.2K

Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs

Anyi Xu1, Dongying Wang1, Bangsheng Chen2

  • 1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.

Frontiers in Cardiovascular Medicine
|December 13, 2024
PubMed

Insights

Intravascular ultrasound (IVUS)-guided stent implantation significantly reduces major adverse cardiovascular events and cardiac death in complex coronary artery disease (CAD). This guidance method offers improved outcomes compared to standard non-IVUS guidance for CAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Imaging

Background:

  • Complex coronary artery disease (CAD) presents significant challenges for effective stent implantation.
  • Intravascular ultrasound (IVUS) offers detailed visualization of coronary anatomy, potentially improving procedural outcomes.
  • The comparative efficacy of IVUS-guided versus non-IVUS-guided stent implantation in complex CAD remains an area of investigation.

Purpose of the Study:

  • To systematically evaluate the efficacy of intravascular ultrasound (IVUS)-guided stent implantation compared to non-IVUS guidance in patients with complex coronary artery disease (CAD).
  • To analyze key clinical outcomes including major adverse cardiovascular events (MACE), myocardial infarction (MI), cardiac death, and revascularization procedures.

Main Methods:

  • A systematic literature search was performed across major databases (PubMed, Web of Science, Cochrane, Embase).
  • Included studies were randomized controlled trials (RCTs) comparing IVUS-guided and non-IVUS-guided stent implantation in complex CAD.
  • Statistical analysis utilized relative ratios (RR) and 95% confidence intervals (CI) to compare outcomes.

Main Results:

  • Six RCTs involving 5,173 patients were analyzed.
  • IVUS guidance was associated with a significant reduction in MACE (RR: 0.63, 95% CI: 0.49-0.82), cardiac death (RR: 0.61, 95% CI: 0.44-0.85), target vessel revascularization (TVR), target lesion revascularization (TLR), and stent thrombosis (ST).
  • No significant differences were found in the incidence of myocardial infarction (MI) or all-cause death between the groups.

Conclusions:

  • Intravascular ultrasound (IVUS)-guided stent implantation demonstrates superior efficacy in reducing adverse cardiovascular events and mortality in patients with complex coronary artery disease (CAD).
  • The findings suggest that IVUS guidance should be considered for optimizing stent implantation strategies in complex CAD cases.
Abstract

Keywords:
IVUSangiographycomplex CADmeta-analysisstent implantation

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.5K
Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

1.4K

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...