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Updated: Jun 5, 2025
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Published on: November 30, 2016
Shared and specific competing endogenous RNAs network mining in four digestive system tumors
Yulai Tang1,2,3, Aamir Fahira2, Siying Lin3
1Key Laboratory of Computer-Aided Drug Design of Dongguan City, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan 523710, China.
This study identifies novel RNA biomarkers and competing endogenous RNA (ceRNA) networks across digestive cancers, offering potential for precision therapies and personalized cancer care. These findings advance understanding of molecular mechanisms in esophageal carcinoma, stomach adenocarcinoma, liver hepatocellular carcinoma, and colon adenocarcinoma.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Digestive system malignancies, including esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), liver hepatocellular carcinoma (LIHC), and colon adenocarcinoma (COAD), represent significant global health burdens.
- Understanding shared and distinct regulatory mechanisms across these cancers is crucial for developing effective, targeted therapies.
- Competing endogenous RNA (ceRNA) networks play a role in cancer development and progression.
Purpose of the Study:
- To construct and compare ceRNA networks across ESCA, STAD, LIHC, and COAD.
- To identify novel RNA biomarkers for these digestive cancers.
- To explore potential precision therapeutic targets for personalized cancer care.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) clinical and transcriptomic data.
- Employed edgeR for differential RNA expression analysis.
- Constructed ceRNA networks using miRcode and ENCORI databases, followed by functional enrichment and prognostic RNA screening.
Main Results:
- Identified 6, 88, 55, and 41 RNA biomarkers in ESCA, STAD, LIHC, and COAD, respectively.
- Network analysis revealed shared elements enriched in cell cycle and mitotic processes, alongside cancer-specific biomarkers.
- Discovered novel biomarkers and identified potential ceRNA regulatory axes in STAD, LIHC, and COAD.
Conclusions:
- This research enhances the understanding of ceRNA networks in digestive cancers.
- Identified RNA biomarkers hold promise as therapeutic targets for personalized treatment strategies.
- The findings contribute to advancing personalized medicine in oncology.
