Related Experiment Video
Updated: Jun 5, 2025
11:19
Robotic Myotomy and Partial Fundoplication for Achalasia
Published on: August 11, 2023
1.4K
Pseudoachalasia Secondary to Metastatic Osteosarcoma
Isha Bansal1, Yogesh Bade1, Amol S Dahale2,1
1Medical Gastroenterology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Cureus
|December 13, 2024
Summary
Pseudoachalasia mimics idiopathic achalasia but is often caused by malignancy. Early diagnosis of pseudoachalasia, especially when linked to cancer, is crucial for improving patient outcomes and guiding appropriate treatment.
Area of Science:
- Gastroenterology
- Oncology
Background:
- Pseudoachalasia presents with symptoms and diagnostic findings similar to idiopathic achalasia.
- However, pseudoachalasia has distinct underlying causes and requires different therapeutic approaches.
Observation:
- A 75-year-old female with metastatic osteosarcoma experienced dysphagia and manometric findings consistent with achalasia.
- Esophagoscopy revealed resistance at the gastroesophageal junction, and CT scan identified a mediastinal mass.
Findings:
- Endoscopic ultrasound-guided biopsy confirmed signet cell tumor cells in the mediastinal deposits.
- The patient's symptoms improved following chemotherapy for inoperable cancer.
Implications:
- Pseudoachalasia can be a secondary condition, frequently associated with malignancy, tumors, surgical complications, or paraneoplastic disorders.
- Timely diagnosis of pseudoachalasia is essential for effective management and improved patient prognosis.
Related Concept Videos
01:21Barrett Esophagus-I: Introduction
64
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
64
01:30Esophageal Strictures-I: Introduction
65
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
65
01:20Myasthenia Gravis: Overview and Treatment
1.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.2K
01:21Barrett Esophagus-II: Clinical Manifestations and Management
104
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
104
01:26Esophageal Strictures-II: Clinical Features and Management
47
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
47
01:26Peptic Ulcer Disease IV: Management
72
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
72