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Risk of Pleural Recurrence in Early-Stage Non-small Cell Lung Cancer in Patients Treated With Surgery vs Stereotactic
Horiana Grosu1, Manuel Cabrera1, Daniella Lizarraga Madrigal2
1Pulmonary Medicine, MD Anderson Cancer Center, Houston, USA.
Cureus
|December 13, 2024
Summary
For non-small cell lung cancer (NSCLC) patients, surgery and radiotherapy showed no difference in ipsilateral pleural recurrence rates. This study compared treatment outcomes for early-stage NSCLC patients.
Area of Science:
- Oncology
- Thoracic Surgery
- Radiation Oncology
Background:
- Pleural recurrence is a concern after lung cancer treatment.
- Surgery as initial treatment may increase pleural recurrence risk.
Purpose of the Study:
- Compare ipsilateral pleural recurrence incidence in non-small cell lung cancer (NSCLC) patients treated with surgery versus radiotherapy.
Main Methods:
- Retrospective cohort study of 512 patients with stage I NSCLC.
- Compared incidence of ipsilateral pleural recurrence after surgical resection or curative-intent radiotherapy.
Main Results:
- No significant difference in ipsilateral pleural recurrence between surgery and radiotherapy groups (P=0.348).
- No difference in overall recurrence (P=0.069) or time to recurrence (P=0.088).
Conclusions:
- Curative-intent surgery and radiotherapy yield similar rates of ipsilateral pleural recurrence in NSCLC.
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