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Merkel cell: Friend or felon.
Ankita Tandon1, Narendra N Singh1, Nikita Gulati2
1Department of Oral Pathology, Microbiology and Forensic Odontology, Dental College, RIMS, Ranchi, Jharkhand, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|December 13, 2024
Summary
Merkel cell carcinomas (MCCs) are aggressive neuroendocrine tumors. Immunohistochemistry aids in diagnosing challenging MCC cases by revealing unique cytokeratin and neurofilament patterns.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Merkel cells, tactile receptors in skin and oral mucosa, are non-keratinocytes.
- Merkel cell carcinoma (MCC) is an aggressive neuroendocrine neoplasm primarily affecting the elderly.
- Common sites include the gingiva and lip vermillion border due to Merkel cell abundance.
Observation:
- MCC histopathology can mimic other carcinomas, necessitating careful diagnosis.
- A specific case presented challenging histopathological features.
- Immunohistochemical analysis was crucial for definitive diagnosis.
Findings:
- The case exhibited a unique cytokeratin profile.
- Neurofilament staining patterns were distinctive.
- These immunohistochemical findings confirmed the Merkel cell origin.
Implications:
- Accurate diagnosis of MCC is vital due to its aggressive nature.
- Immunohistochemistry, particularly cytokeratin and neurofilament markers, is essential for differentiating MCC.
- Understanding Merkel cell biology aids in diagnosing and managing these rare neuroendocrine tumors.
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