Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Organizational Stressors, Burnout, and Mental Health Outcomes Among Local Government Employees During Disaster Response.

Journal of occupational and environmental medicine·2026

Same author

Development of Variable Elastic Band with Adjustable Elasticities for Semi-Passive Exosuits.

Biomimetics (Basel, Switzerland)·2025

Same author

Harnessing resistance: the impact of a passive exosuit on golf swing biomechanics.

Journal of biomechanics·2025

Same author

Low-Profile, Shoe-Type Ankle-Foot Orthosis with Active Variable Ankle Stiffness via Wire-Fabric Compression Mechanism.

Biomimetics (Basel, Switzerland)·2025

Same author

The Impact of the COVID-19 Pandemic on Suicidal Ideation and Depression in Community-Dwelling Elderly.

International journal of geriatric psychiatry·2024

Same author

Improved Assistive Profile Tracking of Exosuit by Considering Adaptive Stiffness Model and Body Movement.

Soft robotics·2024

Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026

Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026

Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026

Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026

Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026

Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2025

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

Reusable EWOD-based microfluidic system for active droplet generation.

Suhee Park¹, Jaewook Ryu¹, Ki-Ho Han¹

¹Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae, 50834, Republic of Korea. mems@inje.ac.kr.

|December 13, 2024

Summary

This summary is machine-generated.

This study introduces an active droplet generation method using electrowetting-on-dielectric (EWOD) for microfluidic applications. This reusable, cost-effective technique offers faster, more precise droplet control than traditional passive methods.

More Related Videos

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jun 5, 2025

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Area of Science:

Microfluidics
Surface Science
Biotechnology

Background:

Droplet generation is crucial for microfluidics but passive methods are slow and require precise flow control.
Electrowetting-on-dielectric (EWOD) offers a tunable surface wettability via electric fields.
Existing methods limit efficiency and applicability in sensitive biological applications.

Purpose of the Study:

To develop an active, reusable, and cost-effective droplet generation method for microfluidics.
To demonstrate the advantages of EWOD-based droplet generation over passive techniques.
To enable precise droplet control for applications like cell encapsulation and drug discovery.

Main Methods:

An active microfluidic device utilizing EWOD was designed for droplet generation.
An electric field was applied to the laminar flow of dispersed and continuous phases.
The EWOD actuation substrate was designed for reusability.

Main Results:

The EWOD method successfully induced droplet formation by discretizing the dispersed thread.
The active method demonstrated fast response speeds and a wider range of controllable droplet sizes.
The use of an ultrathin polymer film allowed for low electrowetting voltage, preserving cell viability.

Conclusions:

EWOD-based active droplet generation is a superior alternative to passive methods in microfluidics.
The developed device offers enhanced speed, versatility, and precision for droplet manipulation.
This technology holds significant promise for advanced applications such as single-cell genomics and drug discovery.