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Human Genetic GLUT1 Deficiency Results in Impaired T Cellular IFN-γ Production

Renske de Jong1, Anandhi Rajendiran1, Judit Turyne Hriczko1

  • 1Department of Pediatrics, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

European Journal of Immunology
|December 13, 2024
PubMed

Abstract:

GLUT1 deficiency prevents glucose uptake in T cells resulting in lower intracellular ATP generation and IFNy production.

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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