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Altered neurovascular coupling in semantic variant primary progressive aphasia
Yanxin Zhang1, Chunxue Ji1,2, Yaping Meng1
1Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Neurovascular coupling (NVC) is impaired in semantic variant primary progressive aphasia (svPPA), impacting cognitive and language functions. This disruption is linked to reduced cerebral blood flow and neural activity in affected brain regions.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Semantic variant primary progressive aphasia (svPPA) is a key frontotemporal lobar degeneration phenotype.
- Observed changes in neuronal activity and perfusion in svPPA suggest potential neurovascular coupling (NVC) breakdown.
Purpose of the Study:
- Investigate NVC alterations in svPPA patients.
- Correlate NVC changes with clinical manifestations in svPPA.
Main Methods:
- 19 svPPA patients and 36 controls underwent multimodal MRI (rs-fMRI, ASL) and neuropsychological testing.
- Amplitude of low-frequency fluctuations (ALFF) and cerebral blood flow (CBF) measured neural activity and perfusion.
- Voxel-wise CBF-ALFF correlation and CBF/ALFF ratios assessed global and regional NVC.
Main Results:
- svPPA patients showed decreased global CBF-ALFF correlation and lower regional CBF/ALFF ratios in temporal regions compared to controls.
- In svPPA, regional CBF/ALFF ratios in the left temporal lobe correlated with naming and general cognition.
Conclusions:
- Neurovascular coupling is disrupted in svPPA.
- NVC alterations are associated with cognitive and language deficits in svPPA.
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