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Related Experiment Video

Updated: Jun 5, 2025

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Association Between Alcohol Use and Primary Open Angle Glaucoma.

Leo L T Meller1,2, Bharanidharan Radha Saseendrakumar1,2, Golnoush Mahmoudinezhad1,2

  • 1Viterbi Family Department of Ophthalmology and Shiley Eye Institute, Hamilton Glaucoma Research Center and Division of Ophthalmology Informatics and Data Science, University of California San Diego.

Journal of Glaucoma
|December 13, 2024
PubMed
Summary
This summary is machine-generated.

Frequent alcohol consumption, defined as four or more drinks weekly, is linked to a higher risk of primary open angle glaucoma (POAG). This association shows a dose-response relationship, particularly pronounced in women.

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Area of Science:

  • Ophthalmology
  • Public Health
  • Epidemiology

Background:

  • Evidence linking alcohol consumption to primary open angle glaucoma (POAG) is inconsistent.
  • The All of Us Research Program offers a diverse dataset to investigate this association.

Purpose of the Study:

  • To examine the relationship between alcohol use frequency and POAG in a diverse population.
  • To identify if alcohol consumption patterns influence glaucoma risk.

Main Methods:

  • Retrospective cohort study utilizing the All of Us Research Program data.
  • Analysis of electronic health records and survey data.
  • Case-control study with a 1:4 ratio, employing regression analyses to assess alcohol use and POAG association.

Main Results:

  • Alcohol consumption of 4+ drinks/week was significantly more prevalent in the POAG cohort (15% vs. 12%).
  • Higher frequency alcohol use was associated with increased POAG odds (OR: 1.22).
  • A dose-response relationship was observed, with monthly or less alcohol use showing increased odds in females (OR: 1.21).

Conclusions:

  • A significant dose-response association exists between alcohol consumption frequency and POAG risk.
  • Consuming 4 or more drinks per week is linked to significantly higher odds of glaucoma.
  • This relationship is more pronounced in female participants.