Recent advances in asymmetric synthesis via cyclopropanol intermediates

Area of Science:

• Organic Chemistry
• Asymmetric Synthesis

Background:

• Cyclopropanols are valuable three-carbon synthons in organic synthesis.
• They undergo diverse transformations via ring-opening or with ring retention.

Purpose of the Study:

• To review stereoselective and stereoretentive transformations of cyclopropanols.
• To highlight their utility in asymmetric synthesis.

Main Methods:

• Summarizing transformations of cyclopropanols.
• Discussing substrate-controlled and catalyst-controlled strategies.

Main Results:

• Cyclopropanols enable various asymmetric transformations.
• Two main strategies are presented: substrate control and chiral catalysis.
• Chiral catalysis offers a recent advancement for nonchiral or racemic cyclopropanols.

Conclusions:

• Cyclopropanols are key intermediates for creating chiral molecules.
• Both traditional and emerging catalytic methods are effective for asymmetric synthesis.