Related Experiment Video
Updated: Jun 5, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Strategies for Optimizing Traditional Exposure and Response Prevention: A Case Study Example in an Adolescent With
Sarah C Jessup1, Amy Mariaskin2, Bunmi O Olatunji1
1Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
None:
Cognitive Behavioral Therapy (CBT) with an emphasis on Exposure and Response Prevention (ERP) has consistently been observed to be an efficacious treatment for obsessive-compulsive disorder (OCD). Although ERP is currently considered the gold-standard, first-line psychological treatment, individuals with chronic fluctuations in symptom presentations or especially severe cases may require additional supplements to exposure that maximize learning and facilitate greater generalization of learning experiences. The present case study serves as an example of how traditional aspects of exposure-based CBT (e.g., psychoeducation, hierarchy building, functional analysis, homework) can be successfully used in addition to leveraging more contemporary stylistic modifications (e.g., explicit expectancy violation, context variability) that may optimize treatment in complex or difficult cases. In the present case study of a patient with contamination-based OCD, functional impairment and disorder symptoms responded to treatment and remained improved at a 3-month follow-up. Implications of the case study are discussed and recommendations are offered for clinicians treating complex or challenging OCD cases.
Related Concept Videos
Operant Conditioning Intervention
In operant conditioning, behaviors that are...
Obsessive-Compulsive Disorder
Behavior Therapy
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Strategies for Assessing and Addressing Confounding
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...

