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Updated: Jun 5, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Nonpharmaceutical Interventions and Neurodevelopmental Outcomes in School-Age Preterm Children and Adolescents: A

Russia Ha-Vinh Leuchter1, Vanessa Siffredi1,2

  • 1Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Journal of Developmental and Behavioral Pediatrics : JDBP
|December 13, 2024
PubMed

Insights

Nonpharmaceutical interventions show limited impact on neurodevelopment in preterm children (aged 4-18 years). More rigorous, large-scale trials are needed to confirm efficacy in this vulnerable population.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • Preterm birth affects neurodevelopment, necessitating interventions for school-aged children and adolescents.
  • Existing nonpharmaceutical interventions aim to enhance cognitive and motor skills in this population.
  • Systematic review to assess the efficacy and methodological quality of these interventions.

Approach:

  • Comprehensive literature search across major databases (Medline, Web of Science, PsycINFO) up to May 2022.
  • Inclusion criteria applied by two independent reviewers.
  • Risk of bias assessed using established tools (RoB 2, RoBINS-I).

Key Points:

  • 23 studies included, with interventions like Cogmed Working Memory Training®, BrainGame Brian, and physiotherapy.
  • Significant bias noted in over 78% of studies (moderate or serious).
  • Limited evidence suggests a constrained impact of current interventions on neurodevelopmental outcomes.

Conclusions:

  • Current research on school-age interventions for preterm neurodevelopment is hampered by methodological limitations.
  • There is a critical need for high-quality, large-scale clinical trials.
  • Further research should focus on robust methodologies to evaluate intervention efficacy in preterm children and adolescents.
Abstract

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