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The C-terminal activating domain promotes pannexin 1 channel opening

Erik Henze1, Jacqueline J Ehrlich1, Janice L Robertson2

  • 1Department of Molecular Medicine, Cornell University, Ithaca, NY 14853.

Proceedings of the National Academy of Sciences of the United States of America
|December 13, 2024
PubMed
Summary

Pannexin 1 (Panx1) channel opening is regulated by a C-terminal activating domain (CAD). This domain repositions the N terminus, altering the pore’s electrostatic landscape to facilitate ion release during apoptosis.

Keywords:
caspase cleavageelectrostatic barrierlarge pore channelmetabolite release

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