Related Experiment Video
Updated: May 7, 2026
06:54
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
11.2K
High Omega-3, Low Omega-6 Diet With Fish Oil for Men With Prostate Cancer on Active Surveillance: The CAPFISH-3
William J Aronson1,2, Tristan Grogan3, Pei Liang1
1Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Summary
A high omega-3, low omega-6 diet with fish oil supplements significantly reduced a key prostate cancer progression biomarker (Ki-67) in men on active surveillance over one year.
Area of Science:
- Oncology
- Nutritional Science
- Prostate Cancer Research
Background:
- Men on active surveillance (AS) for prostate cancer seek dietary interventions to prevent disease progression.
- Omega-3 and omega-6 fatty acids play roles in cellular processes relevant to cancer.
Purpose of the Study:
- To evaluate the effect of a high omega-3, low omega-6 diet with fish oil (D + FO) on prostate cancer cell proliferation.
- To determine if this dietary intervention reduces the Ki-67 index in men with prostate cancer on AS over one year.
Main Methods:
- A phase II, prospective randomized trial involving 100 men with grade group 1 or 2 prostate cancer on AS.
- Participants were randomized to either the D + FO group or a control group.
- Same-site prostate biopsies were analyzed for Ki-67 index at baseline and 1-year follow-up.
Main Results:
- The Ki-67 index decreased by approximately 15% in the D + FO group, while it increased by 24% in the control group.
- A statistically significant difference in the change of Ki-67 index was observed between the groups (P = .043).
- No significant differences were found in secondary outcomes including tumor grade, length, Decipher score, or PSA levels. Four patients in the D + FO group withdrew due to adverse events.
Conclusions:
- A high omega-3, low omega-6 diet with fish oil significantly reduced the Ki-67 index, a biomarker for prostate cancer progression.
- These findings suggest that this dietary intervention may be beneficial for men on active surveillance.
- Further investigation in phase III trials is warranted to confirm these results.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.6K
02:43Mouse Models of Cancer Study
4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K
02:59Cancer Prevention
6.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.5K
01:26Atherosclerosis III: Management
747
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
747