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Assessing alcohol consumption across phosphatidylethanol levels using HDL-cholesterol as a predictor.

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This study shows phosphatidylethanol (PEth) levels correlate with High-Density Lipoprotein Cholesterol (HDL-C), enabling estimation of average daily alcohol consumption in populations. Higher PEth levels indicate increased ethanol intake.

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Area of Science:

  • Clinical Chemistry
  • Toxicology
  • Biomarkers

Background:

  • High-Density Lipoprotein Cholesterol (HDL-C) levels are known to correlate with alcohol consumption.
  • Phosphatidylethanol (PEth) is a direct biomarker of alcohol intake.

Purpose of the Study:

  • To explore the association between phosphatidylethanol (PEth) levels and ethanol consumption.
  • To utilize HDL-C as a surrogate marker for population-level alcohol intake estimation.

Main Methods:

  • Simultaneous measurement of PEth and HDL-C in 50,751 samples from 29,899 patients in Norway.
  • Linear mixed model analyses to assess HDL-C levels within different PEth intervals.
  • Estimation of mean daily ethanol intake based on established HDL-C increase per gram of ethanol.

Main Results:

  • Significant correlations found between PEth and HDL-C levels (Spearman's rho = .385 for women, .420 for men, P < .001).
  • Increasing PEth levels correlated with higher estimated mean HDL-C and thus, higher alcohol consumption.
  • Men with PEth .031-0.100 μmol/L estimated mean daily intake of ~20g ethanol; those with PEth .301-0.500 μmol/L estimated ~51g.

Conclusions:

  • PEth levels can be used to approximate mean daily ethanol consumption at a group level.
  • This method provides an adjunct to existing alcohol consumption assessment tools.
  • Findings support the use of PEth in conjunction with HDL-C for alcohol intake monitoring.