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Assessing alcohol consumption across phosphatidylethanol levels using HDL-cholesterol as a predictor
Alexander Årving1, Thor Hilberg2, Elisabeth Wiik Vigerust2
1Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|December 13, 2024
Summary
This study shows phosphatidylethanol (PEth) levels correlate with High-Density Lipoprotein Cholesterol (HDL-C), enabling estimation of average daily alcohol consumption in populations. Higher PEth levels indicate increased ethanol intake.
Area of Science:
- Clinical Chemistry
- Toxicology
- Biomarkers
Background:
- High-Density Lipoprotein Cholesterol (HDL-C) levels are known to correlate with alcohol consumption.
- Phosphatidylethanol (PEth) is a direct biomarker of alcohol intake.
Purpose of the Study:
- To explore the association between phosphatidylethanol (PEth) levels and ethanol consumption.
- To utilize HDL-C as a surrogate marker for population-level alcohol intake estimation.
Main Methods:
- Simultaneous measurement of PEth and HDL-C in 50,751 samples from 29,899 patients in Norway.
- Linear mixed model analyses to assess HDL-C levels within different PEth intervals.
- Estimation of mean daily ethanol intake based on established HDL-C increase per gram of ethanol.
Main Results:
- Significant correlations found between PEth and HDL-C levels (Spearman's rho = .385 for women, .420 for men, P < .001).
- Increasing PEth levels correlated with higher estimated mean HDL-C and thus, higher alcohol consumption.
- Men with PEth .031-0.100 μmol/L estimated mean daily intake of ~20g ethanol; those with PEth .301-0.500 μmol/L estimated ~51g.
Conclusions:
- PEth levels can be used to approximate mean daily ethanol consumption at a group level.
- This method provides an adjunct to existing alcohol consumption assessment tools.
- Findings support the use of PEth in conjunction with HDL-C for alcohol intake monitoring.
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