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Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Overview of Cell-Cell Junctions01:14

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The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
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Overview of Cell-Matrix Interactions01:24

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Tight Junctions01:29

Tight Junctions

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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Updated: Jun 5, 2025

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Influencing inter-cellular junctions with nanomaterials.

Jinping Wang1, Guoying Zhang2, Kuoran Xing3

  • 1School of Biological Science and Technology, University of Jinan, Jinan 250022, China; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.

Advances in Colloid and Interface Science
|December 13, 2024
PubMed
Summary
This summary is machine-generated.

Nanomaterials can modulate cell-cell junctions for therapeutic benefits. This review explores nanomaterial interactions with cell junctions, their mechanisms, and clinical applications for innovative treatments.

Keywords:
DiseaseE-cadherinIntercellular junctionsNanomaterialsTherapyVE-cadherin

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Materials Science

Background:

  • Cell-cell junctions are crucial for tissue integrity and physiological functions.
  • Disruption of these junctions can cause diseases but also offers therapeutic potential.
  • Nanomaterials show promise in targeting and modulating cell-cell junctions.

Purpose of the Study:

  • To provide a comprehensive review of nanomaterial interactions with cell-cell junctions.
  • To discuss the mechanisms, effects, and therapeutic strategies involving nanomaterial-induced junction modulation.
  • To explore clinical translation challenges and future directions in this field.

Main Methods:

  • Literature review of studies on nanomaterials and cell-cell junctions.
  • Analysis of mechanisms underlying nanomaterial-cell junction interactions.
  • Evaluation of therapeutic strategies and clinical applications.

Main Results:

  • Nanomaterials interact with cell-cell junctions through various mechanisms.
  • These interactions can lead to heterogeneous effects on cellular behavior.
  • Nanomaterial-induced junction modulation offers potential therapeutic strategies.

Conclusions:

  • Nanomaterials represent a promising tool for modulating cell-cell junctions.
  • Further research is needed to overcome challenges in clinical translation.
  • This field holds significant potential for developing innovative therapies.