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07:34
FISH for Pre-implantation Genetic Diagnosis
Published on: February 24, 2011
A 2p;11q chromosome translocation in dysmyelopoietic preleukemia
Cancer Genetics and Cytogenetics
|February 1, 1985
Abstract:
Three patients with dysmyelopoietic preleukemia had a marrow clone with translocation t(2;11)(p21;q23) as the only chromosome change. In one patient, the cytogenetically altered cells disappeared following treatment with 13-cis-retinoic acid. Although these patients did not constitute a homogeneous clinical subgroup, the 2p;11q translocation should probably be added to the short list of nonrandom karyotypic alterations involving 11q23 that have been described in various hematopoietic disorders.
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