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Associations between prenatal exposure to PFAS and cardiometabolic health in preadolescents

Naomi Lejeune1, Elke Rouxel1, Christine Monfort1

  • 1Institut de recherche en santé, environnement et travail (Irset), Univ Rennes, Inserm, EHESP, 9 Av. Professeur Léon Bernard, Rennes, France.

Environmental Research
|December 13, 2024
PubMed

Insights

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) showed no clear link to cardiometabolic health in early puberty. However, some PFAS were associated with reduced adiposity in post-menarche girls, highlighting the importance of pubertal stage.

Area of Science:

  • Environmental Health
  • Pediatric Endocrinology
  • Toxicology

Background:

  • Inconsistent findings exist regarding prenatal per- and polyfluoroalkyl substances (PFAS) exposure and childhood obesity.
  • Few studies have integrated biological markers to assess PFAS effects on cardiometabolic health.
  • Prenatal PFAS exposure is a growing concern for child development and long-term health outcomes.

Purpose of the Study:

  • To investigate associations between prenatal PFAS exposure and cardiometabolic health parameters at age 12.
  • To consider the influence of pubertal stage on these associations.
  • To integrate biological markers for a comprehensive assessment of PFAS impact.

Main Methods:

  • Study included 394 mother-child pairs from the PELAGIE mother-child cohort.
  • Nine PFAS were measured in umbilical cord blood; children underwent clinical examination at age 12.
  • Anthropometry, blood metabolic markers, blood pressure, and a cardiometabolic score were assessed; linear regression and Quantile G-computation models were used.

Main Results:

  • No significant association found between prenatal PFAS exposure and overall cardiometabolic score at age 12.
  • In post-menarche girls, specific PFAS (PFHxS, PFDA) and PFAS mixtures were linked to decreased adiposity and LDL levels.
  • Isolated associations were observed in subgroups, including blood pressure changes and altered lipid profiles.

Conclusions:

  • No clear evidence links prenatal PFAS exposure to cardiometabolic health in early puberty.
  • Inverse associations between PFAS and anthropometric measures were noted in post-menarche girls.
  • Results emphasize the need to consider sex and pubertal stage in PFAS-related health studies.
Abstract

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