Related Experiment Video
Updated: Jun 5, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Association Between High Dietary Advanced Glycation End Products and Periodontitis
Yuehan Zhang1, Jiayu Shu1, Qiyang Ma2
1Department of Stomatology, Guizhou Medical University, Guiyang, Guizhou Province, China.
Objective:
The study aimed to provide evidence for a relationship between a high dietary intake of advanced glycation end products, and periodontitis.
Materials And Methods:
A total of 2334 adults from the National Health and Nutrition Examination Survey (NHANES) during 2003-2004 were included in this study. Binary regression analysis was conducted to measure the association between periodontitis and dietary advanced glycation end products (AGEs), and two adjusted models were constructed to further explore the relationship.
Results:
Participants with AGEs intake above 21.41 U/kcal had a higher prevalence of periodontitis compared to those with lower AGEs intake. After fully adjusting for associated factors, the odds ratios for periodontitis in relation to higher AGEs intake were 1.229 (95% confidence interval 1.015-1.488, p = .034), 1.349 (95% confidence interval 1.157-1.642, p = .003), and 1.331 (95% confidence interval 1.088-1.630 p = .006), respectively.
Conclusions:
Our cross-sectional study reveals a strong association between periodontitis and AGEs.
Clinical Relevance:
An association between advanced glycation end products in the diet and periodontitis implies the importance of the quality of food intake for good oral health.
Principal Findings:
The consumption of dietary advanced glycation end products is associated with an increased susceptibility to periodontitis development.
Practical Implications:
These findings contribute to recognizing the harm of advanced glycation end products in various foods to periodontitis, and guiding clinical oral education.
Related Concept Videos
Proteoglycans
Diabetes: Symptoms, Diagnosis, and Complications
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Diabetes Mellitus: Type 2 and Gestational
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Protein Glycosylation
Glycosylation occurs in...

