The lateral thalamus: a bridge between multisensory processing and naturalistic behaviors

The lateral thalamus (LT) receives input from primary sensory nuclei and responds to multimodal stimuli. The LT is also involved in regulating innate and social behaviors through its projections to cortical and limbic networks. However, the importance of multisensory processing within the LT in modulating behavioral output has not been explicitly addressed. Here, we discuss recent findings primarily from rodent studies that extend the classical view of the LT as a passive relay, by underscoring its involvement in associating multimodal features and encoding the salience, valence, and social relevance of sensory signals. We propose that the primary function of the LT is to integrate sensory and non-sensory aspects of multisensory input to gate naturalistic behaviors.