Validation and clinical impact of motion-free PET imaging using data-driven respiratory gating and elastic PET-CT
André H Dias1, Joshua Schaefferkoetter2, Josefine R Madsen3
1Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark. andre.dias@auh.rm.dk.
Purpose:
Clinical whole-body (WB) PET images can be compensated for respiratory motion using data-driven gating (DDG). However, PET DDG images may still exhibit motion artefacts at the diaphragm if the CT is acquired in a different respiratory phase than the PET image. This study evaluates the combined use of PET DDG and a deep-learning model (AIR-PETCT) for elastic registration of CT (WarpCT) to the non attenuation- and non scatter-corrected PET image (PET NAC), enabling improved PET reconstruction.
Methods:
The validation cohort included 20 patients referred for clinical FDG PET/CT, undergoing two CT scans: a free respiration CTfree and an end-expiration breath-hold CTex. AIR-PETCT registered each CT to the PET NAC and PET DDG NAC images. The image quality of PET and PET DDG images reconstructed using CTs and WarpCTs was evaluated by three blinded readers. Additionally, a clinical impact cohort of 20 patients with significant "banana" artefacts from FDG, PSMA, and DOTATOC scans was assessed for image quality and tumor-to-background ratios.
Results:
AIR-PETCT was robust and generated consistent WarpCTs when registering different CTs to the same PET NAC. The use of WarpCT instead of CT consistently led to equivalent or improved PET image quality. The algorithm significantly reduced "banana" artefacts and improved lesion-to-background ratios around the diaphragm. The blinded clinicians clearly preferred PET DDG images reconstructed using WarpCT.
Conclusion:
AIR-PETCT effectively reduces respiratory motion artefacts from PET images, while improving lesion contrast. The combination of PET DDG and WarpCT holds promise for clinical application, improving PET image evaluation and diagnostic confidence.
