Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two automated methods for measuring plasma thiocyanate compared.

C J Vesey, C J Kirk

    Clinical Chemistry
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity.

    Leukemia·2014
    Same author

    The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

    Leukemia·2012
    Same author

    Raf-1 protein kinase activity in T cells from aged mice.

    Methods in molecular medicine·2012
    Same author

    Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

    Leukemia·2011
    Same author

    Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption.

    The Journal of steroid biochemistry and molecular biology·2007
    Same author

    Substrate characterisation of a recombinant sulfotransferase SULT1 and mRNA expression in chub (Leuciscus cephalus) tissues.

    Biochemical and biophysical research communications·2006
    Same journal

    Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer.

    Clinical chemistry·2026
    Same journal

    Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes.

    Clinical chemistry·2026
    Same journal

    TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations.

    Clinical chemistry·2026
    Same journal

    Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing.

    Clinical chemistry·2026
    Same journal

    Editor's Note: Circulating Proteolytic Products of Carboxypeptidase N for Early Detection of Breast Cancer.

    Clinical chemistry·2026
    Same journal

    In Reply to Reflexing NT-proBNP for sFlt-1/PlGF Ratios That Fall into the Measurement Uncertainty for Preeclampsia Risk Classification.

    Clinical chemistry·2026
    See all related articles

    Two analytical methods for measuring thiocyanate (SCN) in plasma showed strong correlation. Despite minor systematic differences, both accurately classified patients as smokers or nonsmokers, indicating reliable clinical application.

    Area of Science:

    • Clinical Chemistry
    • Analytical Chemistry
    • Toxicology

    Background:

    • Thiocyanate (SCN) is a biomarker for smoking and exposure to certain chemicals.
    • Accurate measurement of SCN is crucial for clinical assessment, particularly in patients with peripheral vascular disease.

    Purpose of the Study:

    • To compare two continuous-flow analytical procedures for plasma thiocyanate measurement.
    • To evaluate the clinical utility of these methods in classifying smoking status.

    Main Methods:

    • Interlaboratory comparison of ferric nitrate and p-phenylenediamine/pyridine colorimetric assays for plasma SCN.
    • Analysis of plasma samples from 100 patients attending a peripheral vascular disease clinic.
    • Correlation analysis and assessment of systematic differences between methods.

    Related Experiment Videos

    Main Results:

    • Both methods demonstrated high correlation (r = 0.987).
    • Small, systematic positive differences were observed between the p-phenylenediamine and ferric nitrate methods.
    • Despite differences, both methods accurately classified patients as smokers or nonsmokers using established cutoff points.

    Conclusions:

    • The two continuous-flow analytical procedures for plasma thiocyanate are comparable for clinical use.
    • Both methods effectively differentiate smokers from nonsmokers, supporting their utility in patient assessment.
    • Adjusting classification based on carboxyhemoglobin levels improved specificity.