Interplay between platelets and coagulation: from protective haemostasis to pathological arterial thrombosis
Gemma Vilahur1,2, Valentin Fuster3
1Research Institute, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Carrer Sant Quintí 77-79, Barcelona 08041, Spain.
European Heart Journal
|December 14, 2024
Summary
This review details haemostasis and arterial thrombosis, focusing on antithrombotic mechanisms and platelet function. Early screening for atherosclerosis is vital to prevent thrombotic events and cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Haematology
Background:
- Haemostasis prevents bleeding via platelet-fibrin plug formation.
- Arterial thrombosis, a pathological process, involves platelet-rich thrombus formation due to atheroma exposure, leading to ischaemic cardiovascular disease.
Purpose of the Study:
- To provide a comprehensive overview of endogenous antithrombotic mechanisms.
- To detail the stages and mechanisms of haemostasis and arterial thrombus growth.
- To elucidate the impact of cardiovascular risk factors on thrombotic events.
Main Methods:
- Review of endogenous antithrombotic mechanisms.
- Detailed analysis of haemostasis stages and platelet function.
- Exploration of cardiovascular risk factors and atherosclerosis screening.
Main Results:
- Endogenous antithrombotic mechanisms maintain haemostatic balance.
- Platelet biology and function are crucial in haemostasis and thrombosis.
- Emerging cardiovascular risk factors promote a pro-thrombotic state.
Conclusions:
- Early screening for subclinical atherosclerosis is crucial for identifying thrombotic risk.
- Proactive interventions to manage atherosclerosis are essential for preventing atherothrombotic disease.
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