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Unveiling cognitive disengagement syndrome: A hidden challenge in children with epilepsy

Cansu Mercan Isik1, Dilek Cebeci2

  • 1Department of Child and Adolescent Psychiatry, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Epilepsy & Behavior : E&B
|December 14, 2024
PubMed

Insights

Cognitive disengagement syndrome (CDS) affects 76% of children with epilepsy, significantly higher than controls. Seizure control and age are key factors associated with CDS in pediatric epilepsy patients.

Area of Science:

  • Pediatric Neurology
  • Child Psychiatry
  • Neurodevelopmental Disorders

Background:

  • Epilepsy in children is often associated with comorbidities.
  • Cognitive disengagement syndrome (CDS) and attention deficit hyperactivity disorder (ADHD) are potential concerns in this population.

Purpose of the Study:

  • To determine the prevalence of CDS and ADHD in children with epilepsy.
  • To identify factors associated with these conditions in pediatric epilepsy patients.

Main Methods:

  • A case-control study involving 62 children with epilepsy (aged 6-18) and 51 healthy controls.
  • Data collection included sociodemographics, epilepsy characteristics, medication use, and psychiatric evaluations using structured interviews and scales.

Main Results:

  • 76% of children with epilepsy exhibited CDS, compared to 26% of controls (p < 0.01).
  • Patients with epilepsy showed higher scores on attention and disruptive behavior scales.
  • Lack of seizure control and age over 12 were linked to higher CDS prevalence. Age, number, and duration of antiseizure medications predicted specific behavioral scores.

Conclusions:

  • This is the first study to investigate CDS and ADHD prevalence in children with epilepsy.
  • Findings underscore the need for research into the mechanisms of CDS in epilepsy and the development of targeted interventions.
Abstract

Keywords:
ADHDCDSChild/adolescentEpilepsy

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