Related Experiment Video
Updated: Jun 5, 2025
10:48
Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression
Published on: May 15, 2014
11.4K
Monkeypox: A comprehensive review on mutation, transmission, pathophysiology, and therapeutics
Somenath Dutta1, Rohan Ghosh2, Ishita Dasgupta3
1School of Chemical and Biomolecular Engineering, Pusan National University, Busan, South Korea; Department of Bioinformatics, Pondicherry Central University, Puducherry, India.
International Immunopharmacology
|December 14, 2024
Summary
Monkeypox virus (Mpox) poses a significant threat, especially to vulnerable groups. This review details Mpox characteristics, transmission, and effective therapeutics, including vaccines and drug therapies, to combat the emerging disease.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Monkeypox virus (MPXV) causes Mpox, a disease declared a Public Health Emergency of International Concern (PHEIC) by the WHO in 2024.
- MPXV infection poses a severe risk to children, pregnant women, and immunocompromised individuals.
- Recent mutational events have led to drug resistance in Mpox.
Purpose of the Study:
- To provide a comprehensive analysis of Mpox, covering its epidemiology, pathophysiology, transmission, and current therapeutic strategies.
- To explore potential targets for novel vaccine and drug development against MPXV.
- To discuss the role of animal models in studying MPXV and developing countermeasures.
Main Methods:
- Literature review and synthesis of existing research on Monkeypox virus (MPXV).
- Analysis of epidemiological data, mutation patterns, and pathophysiology of Mpox.
- Evaluation of current and emerging therapeutic interventions, including vaccines and antivirals.
Main Results:
- MPXV exhibits characteristics that make it a lethal threat, particularly to vulnerable populations.
- Multivalent mRNA vaccines, antibody-based immunotherapy, and combination drug therapies demonstrate significant effectiveness.
- Drug resistance has emerged due to multiple mutational events in MPXV.
Conclusions:
- Effective prevention strategies include hygiene practices and minimizing exposure to infected individuals or animals.
- Advancements in multivalent mRNA vaccines and antibody-based immunotherapies offer promising treatment options.
- Continued research into antivirals, drug resistance mechanisms, and novel therapeutic targets is crucial for combating Mpox.
