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Updated: May 2, 2026

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
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Clinical observation of 4 cases of cerebral infarction caused by left ventricular noncompaction

Yu Shufeng1, Zhong Changyang2, Jin Yi2

  • 1Center for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

The American Journal of Emergency Medicine
|December 14, 2024
PubMed

Insights

Intravenous thrombolysis (IVT) is safe and effective for treating cerebral infarction in adults with myocardial hypertrabeculation. This rare condition

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Myocardial hypertrabeculation is a rare cardiac condition.
  • Cerebral infarction is a serious complication associated with myocardial hypertrabeculation.
  • Optimal management is crucial to mitigate thromboembolic events and stroke risk.

Purpose of the Study:

  • To investigate the safety and efficacy of intravenous thrombolysis (IVT) in adult patients.
  • To assess IVT as a treatment for cerebral infarction in the context of myocardial hypertrabeculation.

Main Methods:

  • Retrospective analysis of clinical data from four adult patients.
  • Evaluation of treatment efficacy and safety of IVT.
  • Prognosis assessment using the modified Rankin Scale (mRS).

Main Results:

  • IVT demonstrated safety and effectiveness in all four adult patients.
  • No hemorrhagic transformation was observed on CT scans 24 hours post-IVT.
  • IVT effectively reduced the severity of cerebral infarction.

Conclusions:

  • Intravenous thrombolysis is a safe and effective treatment option.
  • This approach is suitable for adults experiencing cerebral infarction secondary to myocardial hypertrabeculation.
Abstract

Keywords:
CardiomyopathyDistal medium vessel occlusionExcessive trabeculationIntravenous thrombolysis

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