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Effect of the sarcoptic mange upon metabolome profiling in wild boars

Nadia Piscopo1, Michele Costanzo2, Monica Gelzo2

  • 1Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.

Research in Veterinary Science
|December 14, 2024
PubMed

Insights

Sarcoptic mange in wild boars disrupts metabolism, increasing specific long-chain acylcarnitines during infection. This finding may aid in developing early detection tools for this widespread parasitic disease.

Area of Science:

  • Veterinary Medicine
  • Parasitology
  • Metabolomics

Background:

  • Sarcoptic mange, caused by *Sarcoptes scabiei*, is a significant global health concern for mammals.
  • The disease impacts host physiology beyond skin lesions, including metabolic disturbances, yet the full metabolic burden remains unclear.
  • Early detection of sarcoptic mange is challenging, leading to economic losses and animal welfare issues.

Purpose of the Study:

  • To investigate the metabolic impact of sarcoptic mange in wild boars using metabolomics.
  • To identify potential biomarkers for early detection of sarcoptic mange.
  • To understand the role of specific metabolites in the host's response to infection.

Main Methods:

  • A targeted LC-MS/MS-based metabolomics approach was employed.
  • Blood serum samples from thirteen wild boars were analyzed across three conditions: infected, treated with ivermectin, and recovered.
  • Metabolome profiling was performed to compare biochemical changes.

Main Results:

  • Specific long-chain acylcarnitines were found to be significantly elevated in the blood serum of infected wild boars compared to treated and recovered individuals.
  • These findings suggest a distinct metabolic signature associated with active sarcoptic mange infection.
  • The study provides preliminary evidence for the role of long-chain acylcarnitines in metabolic homeostasis during mange.

Conclusions:

  • Long-chain acylcarnitines show potential as biomarkers for early sarcoptic mange detection in wild boars.
  • Further research is needed to validate these findings and explore their role in metabolic homeostasis.
  • Understanding these metabolic changes can improve disease management and animal welfare.
Keywords:
AcylcarnitinesHigh-throughput approachReservoirSarcoptes scabieiSwineZoonosis

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