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Transformative or transitional? Deciphering the role of NIAGARA in shaping future practice
Daniele Raggi1, Robert A Huddart2
1Genitourinary Oncology, The Royal Marsden Hospital NHS Foundation Trust, Sutton, London, UK.
Abstract:
The phase 3 NIAGARA trial1 demonstrated a statistically significant improvement in event-free and overall survival in cisplatin-eligible patients with muscle-invasive bladder cancer treated with perioperative durvalumab in combination with neoadjuvant chemotherapy, compared to neoadjuvant chemotherapy alone. The combination was manageable and did not adversely impact surgery. NIAGARA positions perioperative durvalumab with chemotherapy as a potential new standard of care.
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