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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

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Aberrant expression in lymphoma, a diagnostic pitfall.

Joo Y Song¹, Zenggang Pan²

¹Department of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.

Human Pathology

|December 14, 2024

Summary

This summary is machine-generated.

Accurately classifying lymphomas relies on cell lineage markers, but aberrant expression poses diagnostic challenges. This review covers aberrant antigen expression in lymphoid neoplasms to improve lymphoma diagnosis.

Keywords:

Aberrant expression B-cell lymphoma Hodgkin lymphoma T-cell lymphoma

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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

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Published on: July 20, 2016

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Published on: October 19, 2014

Area of Science:

Hematopathology
Immunophenotyping
Neoplastic Hematology

Background:

Accurate cell lineage assignment is crucial for lymphoma classification in hematopathology.
Immunohistochemistry and flow cytometry are standard methods for detecting lineage-specific markers.
Aberrant gain or loss of these markers, and expression of non-hematopoietic markers, present significant diagnostic challenges.

Purpose of the Study:

To review the aberrant expression of lineage-associated antigens in mature lymphoid neoplasms.
To provide recommendations for avoiding diagnostic pitfalls in lymphoma classification.
To enhance the accuracy of diagnoses in challenging hematopathology cases.

Main Methods:

Literature review of aberrant antigen expression in mature lymphoid neoplasms.
Analysis of diagnostic challenges posed by aberrant marker expression.
Synthesis of recommendations for accurate lymphoma diagnosis.

Main Results:

Aberrant gain of lineage-associated antigens is a recognized phenomenon in lymphoma diagnosis.
Non-hematopoietic marker expression can occur aberrantly in lymphoid neoplasms.
Diagnostic pitfalls arise from unexpected marker profiles.

Conclusions:

Understanding aberrant antigen expression is key to overcoming diagnostic challenges in hematopathology.
Implementing recommended strategies can improve the accuracy of lymphoma classification.
Accurate diagnosis of mature lymphoid neoplasms relies on careful interpretation of immunophenotypic data.