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Related Experiment Video

Updated: Jun 5, 2025

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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Alcohol use as a risk factor for Clostridioides difficile.

Hala Ashmaig1, Kaia Lindsey2, Sara M Reese2

  • 1Department of Epidemiology, Colorado School of Public Health, Aurora, CO.

American Journal of Infection Control
|December 14, 2024
PubMed
Summary

Individuals with alcohol use disorder (AUD) have a significantly higher risk of developing Clostridioides difficile (C. diff) infection. This risk is further elevated during active alcohol withdrawal, indicating a need for targeted interventions.

Keywords:
Alcohol use disorderC. diff

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Clostridioides difficile (C. diff) infection is a significant healthcare concern.
  • While known risk factors exist, C. diff affects individuals without them.
  • Alcohol use disorder (AUD) impacts gut health similarly to antibiotics, suggesting a potential link to C. diff.

Purpose of the Study:

  • To evaluate the association between alcohol use disorder (AUD) and the risk of Clostridioides difficile (C. diff) infection.
  • To determine if active alcohol withdrawal modifies this association.

Main Methods:

  • Retrospective cohort study conducted in a Colorado health system.
  • Included adult patients admitted to the hospital or seen in the Emergency Department in 2022-2023.
  • Logistic regression analysis used to assess the association between AUD and C. diff.

Main Results:

  • Patients with AUD had 2.36 times greater odds of C. diff infection compared to those without AUD.
  • Individuals with AUD diagnoses alone showed 1.88 times greater odds of C. diff.
  • Patients with AUD and active withdrawal had 1.96 times greater odds of C. diff.

Conclusions:

  • A significant association exists between AUD and an increased risk of C. diff infection.
  • The risk of C. diff is notably higher in patients experiencing active alcohol withdrawal.
  • Findings support earlier interventions for C. diff in patients with AUD, particularly during withdrawal.