Norovirus detection technologies: From conventional methods to innovative biosensors

Area of Science:

• Gastroenterology
• Biotechnology
• Public Health

Background:

• Norovirus (NoV) is a leading cause of acute gastroenteritis with high contagion rates.
• Vaccine development for NoV is significantly challenged by antigenic variation, lack of models, and cultivation difficulties.
• Current effective measures for norovirus outbreaks rely on prevention, early detection, and control.

Purpose of the Study:

• To review and discuss various norovirus biosensors for point-of-care analysis.
• To highlight innovative biosensing techniques for norovirus detection.
• To underscore the role of biosensors in improving norovirus diagnostics and public health response.

Main Methods:

• Review of innovative biosensor technologies for norovirus detection.
• Discussion of electrochemical, colorimetric, fluorescence, and CRISPR-based biosensors.
• Analysis of biosensor performance in detecting norovirus in biological samples.

Main Results:

• Several novel biosensors have been developed for norovirus detection.
• These biosensors demonstrate high sensitivity and specificity in identifying norovirus.
• Various techniques including electrochemical, colorimetric, fluorescence, and CRISPR-based methods are effective.

Conclusions:

• Biosensing techniques offer a promising approach for rapid and accurate norovirus diagnostics.
• The development of point-of-care norovirus biosensors can significantly enhance disease control and prevention strategies.
• Advanced biosensors are crucial for strengthening the global response to norovirus infections and improving public health outcomes.