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The positive implication of natural antioxidants on oxidative stress-mediated diabetes mellitus complications

Shouvik Mallik1, Bijoy Paria1, Sayed Mohammad Firdous1

  • 1Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah, West Bengal, India.

Journal, Genetic Engineering & Biotechnology
|December 14, 2024
PubMed

Insights

Natural antioxidants can help manage diabetes mellitus (DM) by reducing oxidative stress and improving blood glucose levels. These compounds combat complications associated with DM and oxidative stress.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Nutrition Science

Background:

  • Diabetes mellitus (DM) is a growing global health concern, linked to increased superoxide production and impaired insulin signaling.
  • Glycation-derived end products (AGEs) contribute to DM complications by deactivating insulin signaling pathways.
  • Oxidative stress (OS) and reactive oxygen species (ROS) are key factors in DM pathogenesis and inflammation.

Purpose of the Study:

  • To review the role of natural functional antioxidants in managing diabetes mellitus (DM).
  • To explore the association between natural antioxidants and DM-related oxidative stress complications.
  • To highlight the potential of vitamins and phytochemicals as bioactive antidiabetic agents.

Main Methods:

  • Literature review of scientific studies on natural antioxidants and diabetes.
  • Analysis of mechanisms by which antioxidants combat oxidative stress in DM.
  • Examination of the impact of antioxidants on hyperglycemia and epigenetic modifications.

Main Results:

  • Natural antioxidants possess significant potential to reduce oxidative stress and cell damage in DM.
  • These compounds can regulate intracellular ROS, mitigating pro-inflammatory pathways.
  • Antioxidants show promise in controlling epigenetic mutations and normalizing blood glucose levels.

Conclusions:

  • Natural functional antioxidants are crucial for managing DM and its associated oxidative stress complications.
  • Vitamins and phytochemicals offer a complementary approach to DM treatment through their antioxidant properties.
  • Further research into these natural agents can lead to novel strategies for diabetes management.
Keywords:
AntioxidantsDiabetes mellitus (DM)Insulin resistanceoxidative stress (OS)

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