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Evaluating the anti-cancer potential and pharmacological in-sights of Physalis angulata Root Extract as a strong
Jayachithra Ramakrishna Pillai1, Adil Farooq Wali2, Pooja Shivappa3
1Department of Pharmaceutical Chemistry, RAK Medical and Health Sciences University, Ras Al Khaimah, 11172, United Arab Emirates.
Abstract:
The research targeting the prevention of complications through natural constituents, instigated by the cancer has recently drawn much more attention over the globe. The research in this direction also revealed that the use of natural constituents would considered a promising strategy for diminishing the aforementioned disease and its consequences. Because of the easy availability and safe nature, the recent years, natural resources as strong anticancer agents. In this regard, here we introduced the possibility of using the methanolic extract of Physalis angulata root as a strong candidate and implemented the applicability of LC-MS to unveil the presence of various phytocompounds. The anticancer potential exhibited by Physalis angulata root followed by its ability to induce toxicity against the microbial population enhanced the interest in unveiling the phytochemical compounds including Absintholide, Curcumin dimer 1, Mytilin A, Ginsenoside F1, Encecalin , Ganoderic acid TQ, Alnustone, Rhamnetin 3-sophoroside, Gibberellin A14 aldehyde, Thiolutin, Euglobal III and Epomusenin B. The presence of various macro and micronutrients suggested that Physalis angulata is a prominent resource for future research targeting pharmacological research, especially anticancer research.
Insights
Physalis angulata root extract shows anticancer potential and antimicrobial properties. Its phytochemical analysis reveals compounds like Absintholide, Curcumin dimer 1, and Ginsenoside F1, highlighting its promise for cancer research.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products Research
Background:
- Natural constituents are gaining attention for cancer prevention and treatment.
- Natural resources are increasingly recognized for their anticancer potential due to safety and availability.
- Physalis angulata is explored as a potential source of anticancer agents.
Purpose of the Study:
- To investigate the anticancer potential of methanolic extract of Physalis angulata root.
- To identify phytochemical compounds present in Physalis angulata root using LC-MS.
- To evaluate the antimicrobial toxicity of Physalis angulata root extract.
Main Methods:
- Methanolic extraction of Physalis angulata root.
- Liquid Chromatography-Mass Spectrometry (LC-MS) for phytochemical analysis.
- Assessment of anticancer and antimicrobial activities.
Main Results:
- Physalis angulata root extract demonstrated anticancer potential.
- The extract exhibited toxicity against microbial populations.
- LC-MS analysis identified numerous phytocompounds, including Absintholide, Curcumin dimer 1, Mytilin A, Ginsenoside F1, Encecalin, Ganoderic acid TQ, Alnustone, Rhamnetin 3-sophoroside, Gibberellin A14 aldehyde, Thiolutin, Euglobal III, and Epomusenin B.
- Presence of macro and micronutrients was noted.
Conclusions:
- Physalis angulata root is a promising candidate for anticancer research.
- The identified phytochemicals contribute to the observed bioactivity.
- Further pharmacological research is warranted to explore its therapeutic applications, particularly in oncology.
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