Neuro-toxicities of chemo- and immune-therapies in haematologic malignancies: from mechanism to management
David Kegyes1, Vlad Moisoiu2, Catalin Constantinescu1
1Department of Hematology, Ion Chiricuta Cancer Center, Cluj-Napoca, Romania; Department of Hematology / Department of Personalized Medicine and Rare Diseases - Medfuture Institute for Biomedical Research, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Abstract:
Chemo- and immune therapies administered to treat haematologic malignancies frequently cause neurologic injury. The adverse events range from mild cognitive impairment and headaches to severe conditions such as seizures, stroke and encephalitis. We performed a comprehensive literature review and report the types, mechanisms, management and prevention of neuro-toxicity resulting from these therapies in subjects who develop these toxic effects. Our paper will not discuss radiation therapy, as it has already been extensively reviewed by many authors. Our focus will be on recently developed anti-cancer drugs.
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