Development and evaluation of ocular antibiotic-loaded soluble film inserts

Area of Science:

• Ophthalmology
• Pharmaceutics
• Biomaterials Science

Background:

• Frequent antibiotic eyedrop instillation is necessary due to ocular defense mechanisms limiting drug penetration.
• This regimen can lead to poor patient adherence and reduced treatment effectiveness.

Purpose of the Study:

• To develop a biocompatible, fully soluble ocular film insert for improved levofloxacin delivery.
• To optimize the administration procedure considering human eye anatomy and physiology.

Main Methods:

• Solvent casting method using HPMC, sodium alginate, gelatin, and PEG 400 to prepare levofloxacin-loaded inserts.
• Characterization of physicochemical, mechanical, content uniformity, and drug release properties.
• Assessment of antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa.

Main Results:

• Optimized formulation (HPMC E15, low viscosity sodium alginate, type A gelatin, PEG 400) yielded high-quality inserts meeting pharmacopeial standards.
• Inserts demonstrated excellent physicochemical and mechanical properties, suitable for ocular administration.
• Biphasic drug release confirmed sustained levofloxacin levels above minimum inhibitory concentrations, ensuring antimicrobial efficacy.

Conclusions:

• The developed fully soluble ocular film insert offers a promising approach for enhanced ocular drug delivery.
• The formulation exhibits good compatibility with the ocular environment and administration procedures.
• This study provides a adaptable framework for designing and testing ocular drug delivery systems based on ocular characteristics.