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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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Factors affecting inflammatory changes in congenital lung malformations
Andrea Zulli1, Francesca Tocchioni2, Chiara Oreglio2,3
1Department of Pediatric Thoracic Neonatal and Urological Surgery, Meyer Children's Hospital IRCCS, Viale G.Pieraccini 24, 50139, Florence, Italy. andrea.zulli@meyer.it.
Pediatric Surgery International
|December 15, 2024
Summary
Congenital lung malformations (CLMs) frequently show inflammation, particularly congenital pulmonary airways malformations (CPAMs). Early surgery is recommended, as inflammation correlates with age and CLM type.
Area of Science:
- Pediatric Surgery
- Pulmonology
- Thoracic Surgery
Background:
- Congenital lung malformations (CLMs) can lead to pulmonary inflammation.
- Factors influencing inflammation in CLMs require further investigation.
Purpose of the Study:
- To evaluate factors affecting inflammatory changes in patients with CLM.
- To analyze the association between CLM type, age at surgery, and inflammation grade.
Main Methods:
- Retrospective analysis of 105 CLM patients operated between 2005-2021.
- Inflammation assessed using a purpose-made inflammatory score (IS) (0-5).
- Statistical analysis of CLM type and age at surgery versus IS.
Main Results:
- 87% of CLM patients exhibited inflammatory changes (IS: 2.1±1.5 for CPAM, 1.2±1.0 for BPS, 1.3±1.5 for CLE).
- Congenital pulmonary airways malformations (CPAM) showed significantly higher inflammation than bronchopulmonary sequestration (BPS) and congenital lobar emphysema (CLE).
- Younger age at operation (<6 months) correlated with lower IS; age significantly correlated with IS in CPAM and CLE.
Conclusions:
- CLM patients frequently present with inflammation, influenced by anomaly type and surgical timing.
- CPAMs demonstrate the highest inflammation grade.
- Findings support early surgical resection for CLMs, especially CPAMs.
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