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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Factors affecting inflammatory changes in congenital lung malformations.

Andrea Zulli¹, Francesca Tocchioni², Chiara Oreglio^2,3

¹Department of Pediatric Thoracic Neonatal and Urological Surgery, Meyer Children's Hospital IRCCS, Viale G.Pieraccini 24, 50139, Florence, Italy. andrea.zulli@meyer.it.

Pediatric Surgery International

|December 15, 2024

Summary

Congenital lung malformations (CLMs) frequently show inflammation, particularly congenital pulmonary airways malformations (CPAMs). Early surgery is recommended, as inflammation correlates with age and CLM type.

Keywords:

Congenital lung malformation Inflammation score Pediatric surgery Pulmonary resection

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Published on: March 6, 2019

Area of Science:

Pediatric Surgery
Pulmonology
Thoracic Surgery

Background:

Congenital lung malformations (CLMs) can lead to pulmonary inflammation.
Factors influencing inflammation in CLMs require further investigation.

Purpose of the Study:

To evaluate factors affecting inflammatory changes in patients with CLM.
To analyze the association between CLM type, age at surgery, and inflammation grade.

Main Methods:

Retrospective analysis of 105 CLM patients operated between 2005-2021.
Inflammation assessed using a purpose-made inflammatory score (IS) (0-5).
Statistical analysis of CLM type and age at surgery versus IS.

Main Results:

87% of CLM patients exhibited inflammatory changes (IS: 2.1±1.5 for CPAM, 1.2±1.0 for BPS, 1.3±1.5 for CLE).
Congenital pulmonary airways malformations (CPAM) showed significantly higher inflammation than bronchopulmonary sequestration (BPS) and congenital lobar emphysema (CLE).
Younger age at operation (<6 months) correlated with lower IS; age significantly correlated with IS in CPAM and CLE.

Conclusions:

CLM patients frequently present with inflammation, influenced by anomaly type and surgical timing.
CPAMs demonstrate the highest inflammation grade.
Findings support early surgical resection for CLMs, especially CPAMs.