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Left ventricular function before and after reaching the anaerobic threshold.

C A Boucher, M D Anderson, M S Schneider

    Chest
    |February 1, 1985
    PubMed
    Summary
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    In normal individuals, left ventricular ejection fraction (LVEF) significantly increases before the anaerobic threshold during both supine and upright exercise. Further increases in LVEF are not consistently observed after this point.

    Area of Science:

    • Cardiovascular Physiology
    • Exercise Science
    • Pulmonary Medicine

    Background:

    • Understanding left ventricular ejection fraction (LVEF) response during exercise is crucial for assessing cardiac function.
    • The anaerobic threshold marks a significant physiological transition during physical exertion.
    • Previous studies have explored exercise hemodynamics, but the precise LVEF changes relative to the anaerobic threshold in different positions require further clarification.

    Purpose of the Study:

    • To investigate the changes in left ventricular (LV) volumes and ejection fraction (EF) during supine and upright exercise.
    • To determine the relationship between LVEF augmentation and the anaerobic threshold.
    • To compare LVEF responses during exercise in both supine and upright positions.

    Main Methods:

    Related Experiment Videos

    • Simultaneous pulmonary gas exchange analysis and exercise radionuclide angiography were conducted in 24 healthy subjects.
    • Left ventricular (LV) volumes and ejection fraction (EF) were measured at rest, anaerobic threshold, and peak exercise.
    • Exercise was performed in both supine and upright positions.

    Main Results:

    • The anaerobic threshold occurred at similar relative heart rate, workload, and oxygen uptake for both supine and upright exercise.
    • Mean LVEF increased significantly from rest to the anaerobic threshold in both positions, primarily due to reduced end-systolic volume.
    • No further significant increase in LVEF was observed from the anaerobic threshold to peak exercise, especially in individuals with high normal resting LVEF.

    Conclusions:

    • The primary augmentation of LVEF during exercise in normal subjects occurs before the anaerobic threshold, irrespective of exercise position.
    • Beyond the anaerobic threshold, LVEF response can be variable, and a uniform increase is not guaranteed even in healthy individuals.
    • These findings highlight the importance of the early exercise phase for significant LVEF adaptation.