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Updated: Jun 5, 2025

Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay
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Role of PI3Kγ in the polarization, migration, and phagocytosis of microglia

Xinghua Liang1, Yuan Hu1, Xinyue Li1

  • 1Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, China; Chinese Pharmacological Society-Guizhou Province Joint Laboratory for Pharmacology, Zunyi Medical University, Zunyi, 563000, China.

Neurochemistry International
|December 15, 2024
PubMed

Phosphoinositide 3-kinase γ (PI3Kγ) is a signaling protein that is constitutively expressed in immune competent cells and plays a crucial role in cell proliferation, apoptosis, migration, deformation, and immunology. Several studies have shown that high expression of PI3Kγ can inhibit the occurrence of inflammation in microglia while also regulating the polarization of microglia to inhibit inflammation and enhance microglial migration and phagocytosis. It is well known that the regulation of microglial polarization, migration, and phagocytosis is key to the treatment of most neurodegenerative diseases. Therefore, in this article, we review the important regulatory role of PI3Kγ in microglia to provide a basis for the treatment of neurodegenerative diseases.

Keywords:
MicrogliaMigrationNeurodegenerative diseasesPI3KγPhagocytosisPolarization

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