Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model
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View abstract on PubMed
Summary
This summary is machine-generated.Meclizine did not significantly alter the time to central nervous system oxygen toxicity seizures in mice. This suggests meclizine may be a viable option for divers experiencing seasickness while using oxygen rebreather systems.
Area Of Science
- Hyperbaric Medicine
- Neuroscience
- Pharmacology
Background
- Closed-circuit pure oxygen rebreather diving presents risks, including central nervous system oxygen toxicity (CNS-OT) seizures.
- Seasickness is common among divers, with meclizine being a popular treatment.
- Meclizine's anticholinergic and antihistaminergic properties may influence CNS-OT mechanisms involving acetylcholine and glutamate.
Purpose Of The Study
- To investigate the effect of meclizine on the latency to CNS-OT seizures in a hyperbaric oxygen environment.
- To assess the potential of meclizine as a prophylactic agent for divers using pure oxygen systems.
Main Methods
- A randomized crossover study was conducted on 20 male mice.
- Mice were exposed to 608 kPa of oxygen after receiving either a control solution or meclizine.
- Latency to tonic-clonic seizures was the primary outcome measure.
Main Results
- The mean latency to seizure in the control group was 414 seconds (SD 113 s).
- The mean latency to seizure in the meclizine group was 434 seconds (SD 174 s).
- There was no statistically significant difference in seizure latency between the two groups.
Conclusions
- In this animal model, meclizine did not significantly affect the time to CNS-OT seizures.
- Meclizine may be a suitable option for divers experiencing seasickness who utilize pure oxygen rebreather systems.
- Further research is warranted to confirm these findings in human divers.
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