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Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis
Tiing Leong Ang1,2,3,4, Seok Hwee Koo5, Daphne Ang1,2,3
1Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.
Journal of Gastroenterology and Hepatology
|December 15, 2024
Summary
Cholecystectomy (CCE) significantly alters the gut microbiome, leading to dysbiosis. Further research is needed to fully understand these changes and their clinical impact.
Area of Science:
- Gastroenterology
- Microbiology
- Surgical Outcomes
Background:
- Cholecystectomy (CCE) impacts bile acid circulation and gut microbial composition.
- Understanding these post-CCE gut microbiome alterations is crucial for clinical management.
Purpose of the Study:
- To systematically review the effects of CCE on gut microbiome composition.
- To clarify the clinical implications of CCE-induced gut dysbiosis.
Main Methods:
- Systematic literature search across PubMed, Web of Science, and Scopus.
- Included studies analyzed gut microbiome changes post-cholecystectomy.
- Study quality assessed using the Newcastle-Ottawa scale.
Main Results:
- 14 studies revealed significant, though inconsistent, gut microbiome alterations post-CCE.
- Changes observed in microbial diversity (alpha and beta) and phylum/genus abundance.
- Specific shifts noted in conditions like post-cholecystectomy diarrhea and syndrome.
Conclusions:
- Patients undergoing CCE exhibit significant gut dysbiosis.
- Detailed structural and functional gut microbial changes post-CCE remain unclear.
- Further investigation is warranted to elucidate CCE's precise impact on the gut microbiome.
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