Intra-individual variability in voiding diaries of children with enuresis

Area of Science:

• Pediatric Urology
• Clinical Diagnostics
• Urodynamics

Background:

• Voiding diaries are crucial for diagnosing enuresis in children.
• Optimal registration duration for voiding diaries remains undefined.
• Accurate patient characterization is essential for effective enuresis management.

Purpose of the Study:

• To assess intra-individual variability in voiding diary parameters.
• To determine if one week of data suffices for evaluating nocturnal urine production (NUP) and maximum voided volume (MVV) in children with monosymptomatic nocturnal enuresis (MNE).

Main Methods:

• Analysis of 228 14-day voiding diaries from treatment-naïve children (6-14 years) with MNE.
• Nocturnal urine production (NUP) estimated via diaper weight and first morning void volume.
• Maximum voided volume (MVV) recorded with and without the first morning void.

Main Results:

• No significant differences in NUP and MVV between one and two weeks of registration.
• No significant differences when comparing one week versus 14 days of data.
• Subtype characterization changes occurred in 8-12% of children when reducing registration from two weeks to two days.

Conclusions:

• One week of nighttime and two days of daytime voiding diary registration provide valid NUP and MVV estimates.
• Two days of data may suffice for ICCS subtype characterization, potentially improving compliance.
• Shorter voiding diary registration periods can ensure valid diagnostic parameters.