Related Experiment Video
Updated: Jun 5, 2025
Real-Time Void Spot Assay
Published on: February 10, 2023
Intra-individual variability in voiding diaries of children with enuresis
Cecilie Siggaard Jørgensen1, Sofie Nørgaard Pedersen1, Lien Dossche2
1Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Insights
One week of nighttime voiding diary registration and two days of daytime registration are sufficient for accurately assessing nocturnal urine production and maximum voided volume in children with monosymptomatic nocturnal enuresis. This approach may improve patient compliance.
Area of Science:
- Pediatric Urology
- Clinical Diagnostics
- Urodynamics
Background:
- Voiding diaries are crucial for diagnosing enuresis in children.
- Optimal registration duration for voiding diaries remains undefined.
- Accurate patient characterization is essential for effective enuresis management.
Purpose of the Study:
- To assess intra-individual variability in voiding diary parameters.
- To determine if one week of data suffices for evaluating nocturnal urine production (NUP) and maximum voided volume (MVV) in children with monosymptomatic nocturnal enuresis (MNE).
Main Methods:
- Analysis of 228 14-day voiding diaries from treatment-naïve children (6-14 years) with MNE.
- Nocturnal urine production (NUP) estimated via diaper weight and first morning void volume.
- Maximum voided volume (MVV) recorded with and without the first morning void.
Main Results:
- No significant differences in NUP and MVV between one and two weeks of registration.
- No significant differences when comparing one week versus 14 days of data.
- Subtype characterization changes occurred in 8-12% of children when reducing registration from two weeks to two days.
Conclusions:
- One week of nighttime and two days of daytime voiding diary registration provide valid NUP and MVV estimates.
- Two days of data may suffice for ICCS subtype characterization, potentially improving compliance.
- Shorter voiding diary registration periods can ensure valid diagnostic parameters.
Background:
Children with enuresis are often requested to complete voiding diaries in the diagnostic process. There is no consensus on the optimal number of days of registration in the voiding diary that would allow correct patient characterization.
Objectives:
To examine the intra-individual variation in the parameters yielded from voiding diaries and evaluate if one week of registration is sufficient when evaluating the nocturnal urine production (NUP) and maximum voided volume (MVV) in children with monosymptomatic nocturnal enuresis (MNE).
Methods:
We analyzed 228 voiding diaries completed for 14 days from treatment naïve children aged 6-14 years with MNE. NUP was estimated by diaper weight and volume of first morning void. MVV was registered both including and excluding first morning void.
Results:
We found no significant differences in terms of NUP and MVV between week one and two, between one week or 14 days of registration, or when comparing two and four days of daytime registration. When using current ICCS definitions, 8 % of children with reduced MVV and no nocturnal polyuria and 12 % of children with nocturnal polyuria and normal MVV changed characterization when comparing two weeks of registration with two days of registration.
Conclusion:
One week of nighttime-registration and two days of daytime-registration is sufficient to provide valid estimates of NUP and MVV. Two days could be sufficient to calculate subtype characterization according to ICCS definitions and possibly enhance compliance.
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