Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

977
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
977
Development of Immunocompetence01:22

Development of Immunocompetence

283
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
283
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

956
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
956
General Transcription Factors01:30

General Transcription Factors

5.2K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.2K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal resident effector-memory CD4 T cells on the adaptive-innate spectrum comprise IL-18 reactivity and adaptive CMV specificity.

Science advances·2026
Same author

Antibody S22019F Selectively Recognises KIR2DS1 and Enables Analysis of KIR2DS1<sup>+</sup> NK Cells and T Cells.

HLA·2026
Same author

ADAR1 Controls Macrophage Scavenging and Lipid-Buffering Programs in Metabolic Tissues.

European journal of immunology·2026
Same author

EBV Triggers a Distinct Antiviral Response in HMC3 Cells.

bioRxiv : the preprint server for biology·2026
Same author

Human endogenous retrovirus profiling reveals heterogenous expression in cutaneous melanoma.

Frontiers in oncology·2026
Same author

HIV Nef-mediated WAVE2-ARP2/3 inhibition underlies CD4<sup>+</sup> T-cell lamellipodial abnormalities and immune dysfunction.

mBio·2026

Related Experiment Video

Updated: Jun 5, 2025

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
10:23

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

Published on: January 19, 2017

10.9K

Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells.

Inga E Rødahl1, Martin A Ivarsson1, Liyen Loh2

  • 1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

European Journal of Immunology
|December 16, 2024
PubMed
Summary

Human fetal immune cells, called innate lymphoid cells (ILCs), develop early and have distinct tissue distributions. Researchers identified specific progenitor cells in the fetal intestine, suggesting tissue-specific ILC development begins in utero.

More Related Videos

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

4.6K
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

5.4K

Related Experiment Videos

Last Updated: Jun 5, 2025

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
10:23

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

Published on: January 19, 2017

10.9K
Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

4.6K
Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

5.4K

Area of Science:

  • Immunology
  • Developmental Biology
  • Human Fetal Development

Background:

  • The human fetal immune system is crucial for development and maternal-fetal tolerance.
  • Innate lymphoid cells (ILCs) are the first lymphoid cells to emerge in the human fetus.
  • ILCs include natural killer (NK) cells, ILC1s, ILC2s, and ILC3s, originating from a common lymphoid progenitor.

Purpose of the Study:

  • To investigate the distribution, developmental kinetics, and gene expression of fetal ILC subsets and their progenitors.
  • To identify potential tissue-specific progenitor populations for ILCs during human fetal development.

Main Methods:

  • Analysis of ILC subsets (primarily NK cells and ILC3s) and progenitor cells across various human fetal tissues.
  • Characterization of distinct distribution patterns, developmental timelines, and gene expression profiles.

Main Results:

  • Fetal ILC subsets exhibit unique distribution, developmental kinetics, and gene expression profiles across different fetal tissues.
  • Identification of CD34+RORγt+Eomes- and CD34+RORγt+Eomes+ cells in the fetal intestine.
  • These findings indicate the presence of tissue-specific ILC progenitors during fetal development.

Conclusions:

  • Fetal ILC subsets are diverse and develop with distinct characteristics in different tissues.
  • Tissue-specific ILC progenitors are present in the human fetus, particularly in the intestine.
  • This research provides insights into the early development of the innate immune system in humans.