The Association Between Serum Uric Acid Levels and the Risk of Cognitive Dysfunction in Patients With Atrial...

Area of Science:

• Cardiology
• Neurology
• Metabolic Disorders

Background:

• Atrial fibrillation (AF) is associated with increased cognitive dysfunction.
• Serum uric acid levels are implicated in cognitive impairment.
• The optimal serum uric acid threshold in AF patients is not well-defined.

Purpose of the Study:

• To investigate the relationship between serum uric acid levels and cognitive dysfunction in patients with atrial fibrillation.
• To identify a potential threshold for serum uric acid that impacts cognitive health in AF patients.

Main Methods:

• A study involving 583 patients with AF at the Affiliated Hospital of Jining Medical University.
• Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA).
• Statistical analysis included smoothing spline fitting and threshold analysis to examine the association between serum uric acid and cognitive dysfunction.

Main Results:

• The average serum uric acid level was 383.26 ± 110.11 μmol/L, with a 79.76% incidence of cognitive dysfunction.
• A non-linear relationship was observed between serum uric acid and cognitive dysfunction risk in AF patients.
• An inflection point was identified at 352 μmol/L. Below this level, a 2% increased risk of cognitive dysfunction was noted for each unit increase in serum uric acid (OR = 1.02, 95% CI = 1.00-1.04).

Conclusions:

• Serum uric acid levels exhibit a non-linear association with cognitive dysfunction in patients with atrial fibrillation.
• Maintaining serum uric acid levels below 352 μmol/L may be crucial for mitigating cognitive decline risk in AF patients.
• This study provides evidence supporting the management of serum uric acid levels as a therapeutic strategy in AF patients to preserve cognitive function.