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Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...

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Diffuse Large B-Cell Lymphoma Presenting With Hypercalcemia.

Yasser Hegazy¹, Mike Chung², Nicholas Zamora²

¹Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.

|December 16, 2024

Summary

This summary is machine-generated.

This case report details a rare instance of hypercalcemia in diffuse large B-cell lymphoma (DLBCL), caused by ectopic vitamin D production. This finding highlights uncommon mechanisms and potential prognostic implications in DLBCL patients.

Area of Science:

Oncology
Endocrinology
Metabolic Complications

Background:

Keywords:

1`25-dihydroxy vitamin d diffuse large b cell lymphoma (dlbcl)hypercalcemia malignancy-related hypercalcemia non-hodgkin's lymphoma

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Hypercalcemia is a frequent complication of solid tumors but rare in hematologic malignancies like diffuse large B-cell lymphoma (DLBCL).
Common causes of lymphoma-associated hypercalcemia include parathyroid hormone-related peptide (PTHrP) secretion.
Less common mechanisms involve ectopic overproduction of 1,25-dihydroxyvitamin D (1,25(OH)2D) via 1-alpha-hydroxylase activity.