A Case of Rapidly Progressive Glomerulonephritis Associated With Metastatic Melanoma

Pauci-immune glomerulonephritis is a rapidly progressive form of glomerulonephritis. It is distinguished from other rapidly progressive glomerular diseases by the lack of immune deposits seen on renal biopsy, hence the name "pauci-immune." We present a case of pauci-immune glomerulonephritis in a patient with a history of malignancy that was treated with chemotherapy. Notably, the presentation of kidney injury coincided with the discovery of a new metastasis. Prompt treatment of glomerulonephritis is critically important to preserve renal function, though the optimal treatment strategy may not be straightforward in a patient with coexisting malignancy. Ultimately, this case illustrates that collaboration between patients, medical teams, and families is needed to optimize treatment strategy in unique circumstances.