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Related Experiment Videos

Serum creatine kinase in marathon runners.

H Haibach, M W Hosler

    Experientia
    |January 15, 1985
    PubMed
    Summary

    Marathon running significantly elevates serum creatine phosphokinase (CK) and CK-MB levels, especially in slower runners, indicating potential skeletal muscle damage. This is crucial for interpreting cardiac enzyme activity in older athletes post-exercise.

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    Area of Science:

    • Exercise physiology
    • Biochemistry
    • Sports medicine

    Background:

    • Serum creatine phosphokinase (CK) and CK-MB are biomarkers of muscle damage.
    • Marathon running is a strenuous exercise that can induce physiological stress.

    Purpose of the Study:

    • To investigate changes in serum CK and CK-MB activity in trained runners after a marathon.
    • To explore the relationship between running performance and markers of muscle trauma.

    Main Methods:

    • Blood samples were collected from 21 trained runners before and after a marathon race.
    • Serum CK and CK-MB enzyme activities were measured.

    Main Results:

    • Enzyme activities increased two to three times post-marathon compared to pre-marathon levels.
    • The slowest runners exhibited the greatest increases in enzyme activity.
    • This suggests more significant skeletal muscular trauma in less fit individuals.

    Conclusions:

    • Marathon running causes significant skeletal muscle trauma, reflected by elevated CK and CK-MB levels.
    • Slower runners experience greater muscle trauma, highlighting the impact of training status.
    • Findings are important for interpreting cardiac enzyme elevations in older athletes after strenuous exercise.

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