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Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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Related Experiment Video

Updated: Jun 5, 2025

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
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Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle

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Study on the correlation between energy availability and subclinical menstrual disorders.

Zhou Bingzheng1,2, Jin Zhuo3, Wang Qihao2

  • 1Department of Orthopedics and Sports Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Frontiers in Nutrition
|December 16, 2024
PubMed
Summary

Female athletes with subclinical menstrual disorders (SMD) have lower energy availability (EA) than those with normal cycles. Lower EA is linked to a higher risk of developing SMD, highlighting the importance of adequate nutrition.

Keywords:
anovulationenergy availabilitylow energy availabilityluteal phase defectssubclinical menstrual disorders

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Area of Science:

  • Sports Medicine
  • Reproductive Endocrinology
  • Exercise Physiology

Background:

  • Limited research exists on the relationship between energy availability (EA) and subclinical menstrual disorders (SMD) in female athletes.
  • Understanding this correlation is crucial for female athlete health and performance.

Purpose of the Study:

  • To investigate differences in EA between female athletes with eumenorrhea and those with SMD.
  • To determine the correlation between EA and the incidence of SMD in this population.

Main Methods:

  • Fifty-six adult female college athletes with regular cycles were assessed.
  • Energy availability (EA) was monitored, and subclinical menstrual disorders (SMD), including luteal phase defect (LPD) and anovulation, were identified.
  • Statistical analyses compared EA between groups and examined its correlation with SMD.

Main Results:

  • Subclinical menstrual disorders (SMD) were identified in 46.4% of subjects (19 LPD, 7 anovulation).
  • Female athletes with SMD exhibited significantly lower EA compared to those with eumenorrhea (p=0.003).
  • A significant negative correlation was found between EA and the occurrence of SMD (r=-0.396, p=0.000).

Conclusions:

  • Significant differences in EA exist between female athletes with and without SMD.
  • Lower energy availability is a key factor associated with an increased risk of developing subclinical menstrual disorders in female athletes.